Function of cell therapy and genetic engineering methods to treat glioblastoma multiform

Ali Moghimi Khorasgani¹ Dr Farshad Homayouni Moghadam² Dr Mohammad Hossein Nasr-Esfahani³

1) M.Sc. Student of Cellular and molecular biology. ACECR Institute of Higher Education (Isfahan Branch), and Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. E-mail:
2) 2. Assistant professor Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. E-mail:
3) 3. Professor Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. E-mail:

Publication : 2nd. International Congress on science & Engineering - paris(parisconf.com)
Abstract :
Glioblastoma is the most malignant form of brain tumor. Glioblastoma is the primary malignancy in the central nervous system that occurs in the spinal cord or brain. The origin of the tumor is from astrocytic cells. Complications of glioblastoma tumor depend on where the tumor grows. This type of cancer is also the leading cause of death in children and young people. In their most recent activity, brain cancer stem cells have designed the gene to reverse the gene, and have been able to find new ways to treat this type of cancer. In their experiments, they have found several ways to treat glioblastoma, some of which are truly amazing. Glioblastoma stem cells are resistant to treatment and therefore these tumors respond to difficult treatment; So they had to find a new way to treat patients. Researchers have found that gene therapy, genome editing by CRISPR / Cas9, pharmacotherapy and cell therapy are new therapies for the disease. Glioblastoma stem cells have the molecular characteristics of stem cells and neurotransmitters, and it is possible for both forms of normal neurotransmitter cells to spread unchanged, and glioblastoma stem cells in sticky cultures lack defined and defined cells.
Keywords : Glioblastoma stem cell cell therapy Drug therapy .CRISPR/Cas9 gene therapy