LSPR based biosensor for pancreatic cancer’s detection

Maryam Sharifi¹ Balal Khalilzadeh² Farzaneh Bayat³ Ali Vahedi⁴ Habib Tajalli⁵

1) University of Tabriz
2) Tabriz University of Medical Science
3) University of Azarbaijan Shahid Madani
4) Islamic Azad University of Tabriz Branch
5) Islamic Azad University of Tabriz Branch

Publication : International Conference of Biophotonics and Biomedical Optics(icbbo.ir)
Abstract :
This work reports the fabrication of gold nanoparticles on a glass substrate via a high-temperature annealing method for designing a localized surface plasmon resonance (LSPR) biosensor. To obtain gold nanoparticles, a thin film of gold with different thicknesses has been deposited on a glass substrate using the magnetron sputtering method. Then, an eight-hour annealing process has been performed at different temperatures close to the glass transition temperature to form gold nanoparticle islands on the glass substrate. Then, CA-19-9 antibodies are immobilized on gold nanostructures and the identification of the specific antigens are evaluated by the corresponding wavelength shift in LSPR peak wavelength and the light intensity changes.
Keywords : Gold Nano-Structured Substrates Localized Surface Plasmon Resonance Thermal Annealing Optical Biosensor