Effects of bisulfan on changes of serum aminotransferases including ALP, ALT, AST and histopathologic changes of liver tissue in adult male rats

Abdulazim Hossaini¹ Ehsan Larki²

1) Manager Research center
2) Expert of Research center

IOI Code : XCZC-EDABB
Publication : International Conference on Emerging Trends in Engineering, Science and Technology(etest2020.com)
Abstract :
    Effective medicine in treating chroine myelogenovs Leukemia is proved to be Busu lfan and other milloproization which are effectively used these days. Busulfan is derived From Sulfane Alkylo, DNA Alkylation in nuoleus is probably the main actionof these. Medicinesn whichcauses cellular death.this medicine with its alkylating effectve actively outer Nucleus of the bone and is in the carbonium Facters in orgaic intarrals. In this reseanh, the effect of rate of Alp, AST, Altenzymes in Serum is studied in order to assoss liver function and also changes of liver tissue receiving the medicine. The animal used were rats from wistar race wich were provided from animal House of Azad university of kazeroun, Number of animals were 50 Rats with averageweight 200-230 grthat were divided to 50 groups of 10 rats in each experimental , control and sham groups. This medicine was taken in dises 30,60,120(mg/kg) to experimental group for 14 days sham members only received distilled water and of control group they received no thing . A day after the last dosage, Serum Concentrations ALT. AST , ALP eAZmes were measured. In addition to theabove factors, some tissue samples were taken from animals, livers and also tissue change were stidied Results were assessed by using LSD and ANOVA , TukEy tests. Showed that consuming Busulfam in mentioned disages in liver enzymes Showed that wedicine reciv ed dose have no eFFecton Serum Con centration of Alp eAZymes and Alp in the experimental, compared with the control group wich has no significant difference in level of In a ddintion , dosage 30 (ugr/kg) has no effect on ALT. AST. Ans ymas but the experimental Which rece ived 60-120 (ugr/kg) Cornpared with the control group show sign ifiant dufference in level of , so that a significant increase is seen in average of ALT , AST enzymes In these groups compared with the control group. Also tissue studies showed that in jury group has occurred to liver tissue, these chamgeinc lude: destruction of hepatocyts, scattered, focal. In flam mation and congestion of liver vein and sinisoids.

Keywords : busulfan enzymes liver rat hepato hysto pathologic