Evaluation of the relationship between changes in blood glucose and glycated haemoglobin (HbA1c) with changes in liver enzymes in patients referred to the Fajr Hospital, Tehran, Iran

Adel Rahanjam¹ Mahboobeh Talebi Mehrdar²

1) Master of Science, Department of Biochemistry, Payame Noor University, Tehran, Iran
2) Assistant Professor, Department of Biochemistry, Payame Noor University, Tehran, Iran

IOI Code : XEBZ-GDGKC
Publication : Fourth National Conference on Biology (bioconf.ir)
Abstract :
    Introduction: The main risk factors for Non-alcoholic fatty liver disease (NAFLD) are obesity, diabetes, hyperlipidemia, and metabolic syndrome. The best clinical evaluation of the liver function is study of the liver enzymes activity, especially alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. Therefore, the aim of this study was to investigate the relationship between changes in blood glucose and HbA1c factors with changes in liver enzymes in patients referred to Fajr Hospital in Tehran. Methods: Sampling was performed on people who referred to Fajr Hospital in Tehran for a check up test. Finally, samples with SGPT levels above 40 are selected and blood samples are collected in the next test period (6 months later). The changes of four factors of glucose, glycosylated hemoglobin were calculated in these two consecutive visits and finally compared with changes in liver enzymes and the relationship between them was investigated by SPSS V23 software. Results: In the present study, 57 individuals with a mean age of 48 ± 15 years and with SGPT above 40 were included in the study. Among these samples, 6 samples were female (10.52%) and 51 samples were male (89.48%). The results showed that there was no significant relationship between changes in glucose and glycosylated hemoglobin with liver enzymes (p ˃ 0.05). Conclusion: Based on the results of the present study, fasting blood sugar and HbA1c changes in the period of consecutive referral can not be used to follow the treatment of fatty liver (changes in liver enzymes). Keywords: Liver enzymes, Fasting blood sugar, HbA1c

Keywords : liver enzymes fasting blood sugar hba1c