Protective effect of pre-feeding hydro-alcoholic extract of Valeriana officinalis on blood brain permeability in rat stroke model

parnian gilak¹

1) MSc, Dept. of Physiology, Biology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran

IOI Code : XYEZ-AHCHB
Publication : International Conference On Research Science And Technology(rstconf.com)
Abstract :
    Background: Ischemic brain is one of the most complications of stroke and occurs when an artery to the brain is blocked. The purpose of this study was to examine the protective effect of pre-feeding extracts of Valeriana officinalis on blood brain permeability in rat stroke model. Methods: This study was carried out on 5 groups of male Vistar rats. The control groups (Sham and control) received distilled water, while 3 treatment groups received doses of 100, 200 and 400 mL/kg extracts of Valeriana officinalis through gavages for 21 days. Two hours after the last dose, cerebral artery was closed and the stroke was performed and the permeability of the blood brain was measured. Then the results were analyzed by relevant statistical tests (ANOVA and LSD). Finding: Valeriana officinalis extract reduced the blood brain barrier permeability in groups that received doses of 200 and 400 mL/kg in comparison to control group and this was statistically significant (P<0.05). In addition, between the right and left hemispheres of the control group and the group with the dose of 100 mL/kg, a significant difference was observed (P<0.05). Between the right and left hemispheres of the treatment groups with 200 and 400 mL/kg doses, there was no meaningful difference (P>0.05). Conclusion: Although, in this research, treatment by the extract of Valeriana officinalis resulted in reducing of brain permeability, but proving this, requires further investigations. Valeriana officinalis extract has a neuroprotective role due to having high content of anti oxidants such as Valerenic acid.

Keywords : valeriana officinalis neuroprotective stroke vistar rats