Investigation of plasma C-reactive protein (CRP) level in diabetes

Amir Eshaghiyan¹ Pouria Pezeshki² Mosayeb Eghbali³ Maryam Mohammadi⁴ Behnaz Nateghi⁵

1) Department of Genetics, Arsanjan Branch, Islamic Azad University, Arsanjan, Shiraz, Iran.
2) Department of Genetics, Arsanjan Branch, Islamic Azad University, Arsanjan, Shiraz, Iran.
3) Department of Genetics, Arsanjan Branch, Islamic Azad University, Arsanjan, Shiraz, Iran.
4) Department of Genetics, Arsanjan Branch, Islamic Azad University, Arsanjan, Shiraz, Iran.
5) Department of Biochemistry, Faculty of Science, Nourdanesh Institutions of Higher Education, Meimeh, Isfahan, Iran.

Publication : germanconf.com(germanconf.com/2nd)
Abstract :
Globally, about 200 million people have diabetes, but experts believe this number will double by 2030. Ways to prevent or delay the onset of diabetes are, therefore, urgently needed. Some studies have shown the relationship between C-reactive protein (CRP) levels with type II diabetes. Therefore, the aim of this study was to examine the plasma CRP level in Iranian patients with type II diabetes. In the present study, 80 samples, including 40 patients with type II diabetes, and 40 healthy controls were collected. The level of CRP was investigated in type II diabetes patients and healthy controls by Enzyme-Linked Immunosorbent Assay (ELISA). Data were analyzed by SPSS software. Also, diabetes signaling pathway enrichment analysis performed on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Analysis of the level of CRP was a statistically significant difference (P-value<0/005). The level of CRP in type II diabetes increased compared to controls. The findings of the current study revealed the association between the level of CRP and prognosis in type II diabetes, at least in our patients studied. However, more in-depth and comprehensive investigations should be done.
Keywords : Diabetes C-reactive protein Plasma.