Voltammetric PSA sensor based on the use of graphene oxide@polyanilline, and molecular imprinted polymer

maryam banaei¹ ali benvidi²

1) Department of Chemistry, Faculty of Science, Yazd University, Yazd 89195-741, Iran ,E-mail:
2) Department of Chemistry, Faculty of Science, Yazd University, Yazd 89195-741, Iran , E-mail:

Publication : 13th Biennial Electrochemistry Seminar of Iran(elect13pguac.ir)
Abstract :
Prostate cancer is a disease that is characterized by the value of prostate specific antigen (PSA) as a biomarker. In general, it is reported that a men could be suspected to prostate cancer, when a total PSA level in their blood is higher than 4 ngmL-1 [1] or 10 ngmL-1 [2]. While in the female this value of PSA level is lower than10 pgmL-1. This value is 1000-fold less than the value of PSA in male [3]. So, in order to provide proper treatment at the early stage and saving the patients early diagnosis and timely therapy can be useful [4]. This paper focuses on a sensitive and selective electrochemical method to detect PSA by using molecularly imprinted polymer (MIP). A composite of graphene oxide - poly aniline (GO@PA) has been introduced into the electrode. In the MIP sensor, GO@PA on the surface of modified electrode is employed to immobilize PSA to the surface of the electrode and dopamine is used as a monomer to capture PSA in the polymer matrix. To follow the electrochemical signal under the optimum condition differential pulse voltammetry is used as a simple and sensitive detection. The detection range for the determination of PSA was obtained in the concentration of PSA in the range of 25 pg mL−1 to 2.5 ng mL−1. Also the designed GO@PA-MIP sensor showed the application of this method for early diagnosis of prostate cancer.
Keywords : voltammetric sensor graphene oxide polyanilline molecular imprinted polymer