Electrochemical Oxidation of Diclofenac in the Presence of Toluenesulfinic acid

saeedeh shahparast¹ Davood Nematollahib²

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Publication : 13th Biennial Electrochemistry Seminar of Iran(elect13pguac.ir)
Abstract :
Electrochemical methods are widely used for the study of electroactive compounds in pharmaceutical forms and physiological fluids [1]. It is used for the synthesis of some new organic compounds due to their simple, accessible, and practical properties, in addition being consistent with the principles of green chemistry [2]. Also, Aryl sulfones are important synthetic targets. They are useful in the practice of medicinal chemistry. Our interest in the design and electrochemical synthesis of new compounds prompted us to synthesize new molecules under mild and ambient conditions [3]. In this work, The electrochemical behavior of Diclofenac have been studied in various pH values in the presence of Toluenesulfinic acid nucleophile in aqueous solutions. The results indicate that from oxidation of Diclofenac participates with arylsulfinic acids to form the corresponding new sulfone derivatives. The mechanism of anodic oxidation of Diclofenac has been successfully performed under constant current condition in good yield and purity in an undivided cell. The results indicate oxidation of Diclofenac in the presence of Toluensulfinic acid was happened by EC mechanism
Keywords : Electrochemical oxidation Cyclic voltammetry Diclofenac