Electrochemical oxidation of 2,3-dihydroxypyridine in the presence of arylsulfonic acid

hamed goljani¹ matin alvandi² davood nematollahi³

1) student
2) student
3) professor

Publication : 13th Biennial Electrochemistry Seminar of Iran(elect13pguac.ir)
Abstract :
Among pyridine derivatives, hydroxypyridines have attracted scientific interest in areas such as pesticide design[1]. clinical therapeutics and pharmacology [2,3]. In this work, we study Electrochemical behavior of 2,3-dihydroxy pyridine in the various pHs using cyclic voltammetry to investigate the acidic dissociation constant. Some new unsymmetrical diaryl sulfones were synthesized by anodic oxidation of 2,3-dihydroxy pyridine in aqueous solutions in the presence of arylsulfonic acids at a carbon electrode. The data show that the electro generated pyridine-2,3- dione was converted to the unsymmetrical diaryl sulfones by Michael type addition reaction with ECE mechanism. This work has led to the development of a high yield, green, reagentless and facile electrochemical method for the synthesis of the described sulfones.
Keywords : electrosynthesize 2 3-dihydroxy pyridine arylsulfonic acid