Investigation the release of Frankincense from PMBN Nanopolymer for use in Alzheimer s treatment

Farimah moazzam¹ Ashrafalsadat Hatamian-Zarmi² Bahman Ebrahimi Hosseinzadeh³ Zahra Beagom Mokhtari-Hosseini⁴ Puria Motamed Fath⁵

1) Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran ,
2) Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran ,
3) Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran ,
4) Faculty of Petroleum and Petrochemical Engineering, Hakim Sabzevari University,Sabzevar, Iran
5) Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran ,

Publication : International Conference on Engineering & Technology - Norway (12icet.com)
Abstract :
Frankincense (Boswellia Species), the resinous extract from the trees of the genus Boswellia, has been used for centuries in cultural ceremonies, as a cosmetic agent, and as a traditional medicine to treat a variety of ailments. Some studies have shown that the use of frankincense can also improve the learning and enhance the memory in animals and human beings. Drug delivery to the brain represents one of the most important challenges in the field of nanomedicine, as the study and planning of nanocarriers able to cross the blood brain barrier are topics at the cutting edge of technology and innovation. Poly [2-methacryloyloxyethyl phosphoryl choline (MPC)-co-n-buthyl meth¬acrylat (BMA)-co-p-nitrophenyl-oxycrabonyl poly ethylene glycol-methacrylate (ME¬ONP)] (PMBN), a biocompatible terpolymer, is a unique polymer with applications that range from drug delivery systems (DDS) to biomedical devices. In the current study, we used the conventional radical polymerization method to synthesize the water soluble, amphiphilic terpolymer, PMBN.containing Frankincense and characterized by different assays to determine its properties such as particle size, zeta potential (ZP), and drug encapsulation efficiency (EE) . In addition, drug release was also studied. Frankincense-PMBN with a mean size of 70 ± 0.8 nm, a ZP of -2.9 mV, and an EE of 84.35% were obtained. By investigating release of Frankincense from PMBN was found nanoparticles have a slow release in neutral medium and Followed Higuchi model. A critical overview of these aspects will help in better understanding the status of nanomedicine in the application to central nervous system pathologies along with the future directions.
Keywords : Frankincense nanoparticles PMBN drug delivery systems drug release