Investigation of Kartogenin release from PLGA microspheres by in situ and external sink method

Pariya Zare¹ Zohreh Bagher² Hamid Rashedi³

1) MSc Student, School of Chemical Engineering, College of Engineering, University of Tehran
2) ENT and Head & Neck Research Center and Department, The Five Senses Institute, Iran University of Medical Sciences (IUMS)
3) Associated Professor, School of Chemical Engineering, College of Engineering. University of Tehran

Publication : International Conference on Engineering & Technology - Norway (icetconf.com)
Abstract :
Release characterization of Kartogenin (KGN) as a new small molecule by the conventional media remains a challenge due to its hydrophobicity; thus, the novel external sink method utilized. The present study attempted to investigate the in vitro release of KGN, which incorporated in poly-d,l-lactide-co-glycolide (PLGA) microparticles in two different release media, including conventional and external sink media and their results were compared. Using Heptane as a release media in the external sink method could biomimetic the hydrodynamic body environment. Microparticles characterized by the scanning electron microscopy analysis (SEM), which have round and homogenized morphology. The most important application of KGN is in chondrocyte differentiation; thus a comparison of these two release media for achieving a higher amount of released drugs is valuable. Generally, utilizing PLGA in drug delivery is a promising system for cartilage tissue engineering.
Keywords : Kartogenin Drug delivery PLGA External Sink Method