Synthesis of DEX – loaded PLGA nanoparticles: The effect of sonication power on size distribution

Niki Jenabi¹ Sadaf Saeedi Garakani² Zohreh Bagher³

1) University of Tehran,
2) University of Tehran
3) Iran university of medical science

Publication : International Conference on Engineering & Technology - Norway (icetconf.com)
Abstract :
Nanoparticle drug delivery systems seem to be a viable and promising strategy for the biopharmaceutical industry. They may enhance the bioavailability, solubility, and permeability of many potent drugs which are otherwise difficult to deliver orally. Nanoparticle drug delivery systems will also reduce drug dosage frequency and will increase patient compliance. PLGA-based nanoparticles may increase the efficacy of treatments because of the sustained release of the therapeutic agent from stable nanoparticles. They can improve pharmaco-kinetic and pharmaco-dynamic profiles. In the present study, PLGA nanoparticles containing dexamethasone were prepared by using an oil-in-water (o/w) emulsion solvent extraction/evaporation technique and were characterized by their mean size and scanning electron microscopy (SEM) to develop a controlled release system. The FTIR spectra of PLGA and PLGA nanoparticles were observed which came as no different. The analytical method for the quantification of dexamethasone by ultraviolet-visible spectrophotometry was validated. The results indicate that it was possible to prepare particles at a nano-metric size because the average diameter of the drug-loaded PLGA particles was 200 nm. The drug encapsulation efficiency was 84%. The in-vitro tests showed that about 45% of the drug was released in 2 h and 99% of the drug was released in 168 h.
Keywords : PLGA Nanoparticles controlled drug delivery Dexamethasone