Synthesis of molecularly imprinted polymers for the application of selective Vindesine as Novel Drug Delivery System

Mina Ghavidel Marghzari¹ Kowsar Dolatiari² Dana mohammadi³

1) Department of Medicinal Chemistry, Ghadr university of Kochesfahan, Guilan, Iran
2) Department Pure Chemistry, Razi university of Kermanshah
3) Occupational Health Engineering (Health Professional) , Azar Abadgan University of Urmia

Publication : 2nd. International Congress on science & Engineering - paris(parisconf.com)
Abstract :
For the first time in this work, molecularly imprinted polymers (MIPs) nanosphere for Vindesine have been synthesized by precipitation polymerization. Molecularly imprinted polymers (MIPs) are synthetic tailor-made polymers with high selectivity towards a particular substance (template). An MIP using Vindesine as the template molecule was synthesized and characterized. The presence of monomer-template complexes in a non-covalent way was confirmed by UV-vis spectrometry analysis. The polymerization was performed using methacrylic acid (MAA) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent, and toluene as the porogenic solvent by a thermo-polymerization method. The characterization of the obtained MIP was evaluated by scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) analysis. It was observed that the morphology of the MIP was more porous and rough, and the surface area had a significant increase compared with that of the non-imprinted polymer (NIP). Vindesine was specifically adsorbed on the MIP cartridge, while to Vindesine, the chemical analog of Vindesine, almost no selective binding appeared. The solvents dissolving the samples had significant influence on the capacity of the MIP cartridge; it was 750 μg/g in toluene, 625 μg/g in chloroform, and 250 μg/g in methanol.
Keywords : molecular imprinting polymer Vindesine Controlled release