Effect of loaded frankincense extract on polymer and solid lipid nanoparticles on an animal model of Alzheimer s

Farimah Moazzam¹ Ashrafalsadat Hatamian-Zarmi² Bahman Ebrahimi Hoseinzadeh³ Fariba Khodagholi⁴ Hale Alvandi⁵

1) Department of Life Science Engineering, Faculty of New Science and Technology, University of Tehran, Tehran, Iran
2) Department of Life Science Engineering, Faculty of New Science and Technology, University of Tehran, Tehran, Iran.
3) Department of Life Science Engineering, Faculty of New Science and Technology, University of Tehran, Tehran, Iran.
4) Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5) Department of Life Science Engineering, Faculty of New Science and Technology, University of Tehran, Tehran, Iran.

Publication : 3rd International Congress On Engineering, Technology and Innovation(eticong.com/3rd)
Abstract :
Alzheimer s disease is an age-related degenerative brain disorder. The exact cause of this disease has not been determined and the available drugs only delay the progression of the disease. Studies show that plant compounds such as frankincense extract can be considered as a powerful therapeutic agent to prevent this disease. This extract reduces the progression of Alzheimer s and also significantly increases nerve growth and nerve branching. However, these compounds do not have good stability and solubility. In this study, frankincense extract was loaded on polymer nanoparticles and solid lipid nanoparticles. These nanoparticles were targeted by lactoferrin binding. Then the effect of these nanoparticles on the animal model of scopolamine-induced amnesia was investigated. The size of PMBN polymer nanoparticles after binding to lactoferrin was 106.6 nm and its zeta potential was -3.8 mV. The size of SLNs after binding to lactoferrin was 103 nm and its zeta potential was -29.2 mV. FESEM images confirmed the formation of spherical SLNs and PMBN rod nanoparticles. The binding of lactoferrin to the nanoparticle surface was confirmed by FTIR. The release rate of the drug after 48 hours was 21% in PMBN polymer nanoparticles and 50% in SLNs. Investigation of the effect of these nanoparticles in animal models showed Lf-PMBN and Lf-SLN had the highest effect on improving memory, depression, and stress. These results indicate that nanoparticles loaded with frankincense extract could be a good option for curing Alzheimer s disease.
Keywords : Alzheimer s Frankincense Polymer SLNs.