Synthesis of MNPs@AP@NIPAAm in order to increase the delivery of ceftazidime: in vitro study

Vida Jodaian¹ Arash Alipour² Marzieh Mehdizadeh³ Zahra Ahmadpour Param⁴ Mehrshad Azizzadeh Ghaleichi⁵ Behnam Abbasi Kalashi⁶ Mahdi Maleki Viri⁷

1) Department of Chemistry, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran,
2) Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran,
3) Department of Chemistry, Islamshahr Branch, Islamic Azad University, Islamshahr,
4) Department of Chemistry, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran,
5) Department of Chemistry, Islamshahr Branch, Islamic Azad University, Islamshahr,
6) Department of Chemistry, Islamshahr Branch, Islamic Azad University, Islamshahr,
7) Department of Chemistry, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran,

Publication : 3rd International Congress On Engineering, Technology and Innovation(eticong.com/3rd)
Abstract :
In this paper, a novel method is investigated for extraction, determination, and delivery of ceftazidime in simulated gastric and real biological fluids such as serum plasma and urine in the in-vitro drug delivery system. A new polymer as nano-sorbent was synthesized by surface grafting of [N-isopropylacrylamide-co-3-allyloxy-1,2-propanediol] onto modified magnetic nano-particles by 3-mercaptopropyltrimethoxysilane and was characterized by FT-IR, CHN, SEM, TEM, VSM, TGA, and Zeta Potential. The effect of main parameters such as pH, reaction time, temperature and solvents on ceftazidime were evaluated. The results indicated the newly synthesized polymer can be successfully applied for biomedical applications and drug delivery.
Keywords : Ceftazidime; Drug delivery; Magnetic nano-particles polymer grafting