Coupling Co-Metal-Organic Framework and Molecularly Imprinted Polymer for Enhanced Amphotericin B Detection

Moghadaseh Yahyapour¹ Maryam Malekzadeh² afroozeh.arabi³

1) Department of Chemistry, Shahid Bahonar University, Kerman, Iran, E-Mail-Adresse:
2) Department of Chemistry, Payame Noor University, Tehran, Iran, E-Mail-Adresse:
3) Department of Chemistry, Payame Noor University, Tehran, Iran, E-Mail-Adresse:

Publication : 3rd International Conference on New Research & Achievements in Science, Engineering & Technologies(setbconf.com)
Abstract :
This study presents the development and application of a highly sensitive Co-Metal-Organic Framework/Molecularly Imprinted Polymer/Glassy Carbon Electrode (Co-MOF/MIP/GCE) sensor for the precise detection of Amphotericin B (AmB). The sensor s performance was meticulously optimized, resulting in impressive attributes. It boasts a wide linear detection range spanning from 0.1 µM to 1800 µM, with a remarkably low limit of detection (LOD) of 0.01 µM and a limit of quantitation (LOQ) of 0.1 µM, underscoring its exceptional sensitivity. The method s precision is exemplified by a relative standard deviation (RSD) of less than 0.014%. Furthermore, real sample analysis demonstrated the sensor s practical utility, achieving recovery rates between 94.8% and 102%. This Co-MOF/MIP sensor presents a highly promising solution for AmB analysis, with significant potential applications in pharmaceutical quality control and clinical drug monitoring.
Keywords : Molecularly imprinted polymers; Amphotericin B; Metal-organic framework; Electrochemical sensor