Adipose-derived Stem Cell Exosomes: Tiny Messengers with Big Potential in Wound Healing

Mahnaz Shavandi¹ Seyedeh Sara Shafiei²

1) Stem Cell and Regenerative Medicine Department, Institute of Medical Biotechnology, National Institute of Genetic Engineering & Biotechnology, Tehran, Iran. Email
2) Stem Cell and Regenerative Medicine Department, Institute of Medical Biotechnology, National Institute of Genetic Engineering & Biotechnology, Tehran, Iran. Email.

IOI Code : XKBA-AAAAHC
Publication : 3rd International Conference on Recent Advances in Engineering, Innovation and Technology - Belgium(eitconf.com/3rd)
Abstract :
    Adipose-derived stem cell (ADSC) exosomes are increasingly recognized as a promising therapeutic modality for enhancing wound healing, owing to their proficiency in delivering bioactive molecules that support tissue repair and regeneration. These nanosized vesicles are rich in various growth factors, cytokines and microRNAs, which play crucial roles in modulating cellular functions such as inflammation, proliferation, migration, and angiogenesis. Empirical studies indicate that ADSC-derived exosomes can significantly accelerate wound healing processes by promoting re-epithelialization, increasing collagen synthesis, and stimulating neovascularization. Their small dimensions and capability to penetrate biological barriers position them as ideal candidates for the direct delivery of therapeutic agents to the site of injury. This review examines the underlying mechanisms by which ADSC exosomes facilitate wound healing and explores the potential challenges and future directions for their application in clinical settings.

Keywords : adsc derived exosomes wound healing angiogenesis stem cell micro rna