The mechanism of miR-21 in OSCC

mona peyman¹ solmaz alihosseini² yousef arianmehr³ Saeed Hesami Takallu⁴ hakimeh zali⁵

1) iran, university of science.
2) iran, university of science.
3) iran, university of science.
4)
5)

Publication : International Conference On Research Science And Technology(restconf.org)
Abstract :
Oral squamous carcinoma cancer (OSCC) is the most common types of head and neck cancer (HNSCC). OSCC the sixth solid cancer in worldwide. With convenient access to examination and biopsy of cancerous tissue, causing people are high mortality is diagnosed in advanced stages of OSCC. According to reliable molecular markers that provide early detection OSCC, Prognosis Prediction and they are dedicated to treating patients. With this commentary, small non-coding RNA can play a role in cancer detection. Mir-21 in OSCC promoting effects, microRNA are able to regulate gene expression down. Mir-21 on the differentiation, diversity, apoptosis and metastasis plays a role. Target linked to the miR-21 extracted from the target scan database. And mechanisms related to targets of miR-21 with genetrail 2 were checked. In Go-biological process detected of the similarity between cancer cells and embryonic cells were clearly marked. By focusing impact mir-21, receptor PDCD4 arrived in OSCC‘s invasion, metastasis and differentiation. After more studies can be used to identify other receptors to treat and diagnose OSCC, to be inhibited metastasis. . ASO (antisense oligonucleotide) with the effects of the two receptor (PTEN and TPM1) inhibits miR-21. Mir-21 is recommended for other drugs that could inhibit, such as CI-1033 to examine from drug bank for OSCC, it is part of effective drugs against cancer. Finally mir-21 can be used as a predictive of poor prognosis for OSCC so can be on the path of cure the disease has been faster progress.
Keywords : oral cancer microRNA database