Evaluation of leptospira interrogans outer membrane protein Ompl37 linear and conformational epitopes

Afsane Bastani Allah abadi¹ Fateme Sefid² Sara Sabet³ Sadaf Jelvani⁴ Fahime sadat Mousavi zade⁵

1) Undergraduate student of biotechnology of science and art University, Yazd, Iran
2) Graduate student of cell and molecular of shahed University, Tehran, Iran
3) Undergraduate student of biotechnology of science and art University, Yazd, Iran
4) Undergraduate student of biotechnology of science and art University, Yazd, Iran
5) Undergraduate student of cell and molecular of science and art University, Yazd, Iran

Publication : International Conference on Science and Engineering(2icesconf.com)
Abstract :
Leptospirosis is a tropical, neglected, zoonotic disease caused by pathogenic spirochetes of the Leptospira genus. It is typically associated with inadequate sanitation, poverty, and recreational or professional activities that involve exposure to known risk factors(1-2). Transmission occurs mainly through direct or indirect contact with the contaminated urine of reservoir animals[3]. The infection is endemic wherever there is exposure to urine of reservoir host animals that harbor the organism in their renal tubules. Commercially available vaccines are bacterin-based (killed whole cells), do not provide cross-protection against different serovars, confer only short-term immunity and usually fail to prevent the transmission of the disease [11-12]. Efforts to develop recombinant vaccines against leptospirosis have focused on conserved outer membrane proteins (OMPs) that represent potential targets for immunological defence mechanisms. The aim of this study was to characterize and evaluate the linear and conformational epitopes of the outer membrane protein Ompl37 in leptospira interrogans as a vaccine candidate.
Keywords : Linear and conformational epitopes Ompl37 vaccine candidate leptospira