Construction of biocompatible molecular imprinting polymer based on chitosan and used of MWCNTs as a platform for electrochemical sensing of norepinephrine

maryam banaei¹ Ali benvidi²

Abstract :
Norepinephrine is one of the catecholamine neurotransmitter which is released from the nerve ending in the sympathetic nervous system [1, 2]. Some disease such as stress, a fall in blood pressure and depression can be related to abnormal level concentration of norepinephrine [3]. Then fabrication of suitable device to determine of norepinephrine is important. In this work electrochemical sensor coupled with molecular imprinted polymer (MIP) was constructed. The use of MWCNTs as a support material enlarges the sensing area on the glassy carbon electrode, while the MIP film from chitosan as a biocompatible and natural polymer warrants improved selectivity for epinephrine. Quantification of the template on the MWCNTs@chitosan film was performed by employing hexacyanoferrate as the electrochemical probe. Scanning electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy were applied to characterize the sensor materials. Influencing factor such as the percent of MWCNTs, the electropolymerization time, and the elution condition were optimized. The design sensor show linear range from 5×10-8M to 1×10-6 M for detection of norepinephrine by differential pulse voltammetry. The detection of norepinephrine in serum sample by using chitosan (MIPs)/MWCNTs sensor also gave satisfactory results.
Keywords : Molecular imprinting polymer, Electrochemical sensor, Norepinephrine, Chitosan, Differential pulse voltammetry.

زبان مقاله : انگلیسی
محور مقاله : الکتروشیمی تجزیه ای
محل انتشار : سیزدهمین سمینار دوسالانه الکتروشیمی انجمن شیمی ایران
آدرس وب سایت کنفرانس : elect13pguac.ir
ارسال کننده : مریم بنائی
کد IOI مقاله : XBCG-DCBAE
لینک مستقیم مقاله : https://isnac.ir/XBCG-DCBAE