پیام رسان بله
جستجو
In silico evaluation and prediction of intra/inter-species relationships & properties of antigenic region 4 of HA protein of swine influenza H1N1 virus in Iran in order to present a proper candidate for vaccine
Niloufar Haji beigy1 Shiva Dehghan2 Alireza Iranbakhsh3 Mohammadreza Shafaati4
Abstract :
Four antigenic regions exist on the globular domain of hemagglutinin (HA) surface
antigen that amino acids substitutions caused by point mutations in these regions have
been intensified (1). The purpose of this study was in- silico evaluation and prediction
of intra/inter-species relationships and properties of antigenic region 4 of HA protein of
swine influenza H1N1 virus in Iran in order to present a proper candidate for protective
vaccine against this virus.
In this study, the software based investigations on the genomic region of antigenic
segment 4 of HA protein of swine influenza H1N1 virus in Iran and the evaluation of
specific intra/inter-species relationships in this hydrophilic region as well as the
prediction of antigenic sites of it, were done.
The genomic sequence of antigenic segment HA protein gene of swine influenza H1N1
virus is 1701 bp. By using the Bio-Edit software, we evaluated the sequence similarity
between the other 25 species and the accordance as well as the entropy of them was
calculated. The data obtained from the bioinformatics studies showed that there are
many similarities between segment 4 of H1N1 virus isolated from Iran and segment 4
of H1N1 virus isolated from Kerala, Sydney, Qingdao, Egypt, Bangkok and England.
In this research, the study of antigenic segment 4 HA protein gene of swine influenza
H1N1 virus and phylogenetic analysis of it, showed that the strain isolated from Iran
have many similarities as compared with the strain isolated from the countries that
mentioned above and the basis of done predictions, production of a protective vaccine
against each of these strains can be effective against the other one. Therefore, it can be
designed, an effective and efficient vaccine against this virus, in view of obtained information.
Keywords : influenza a virus h1n1 subtype vaccine interspecies relationship bioinformatics study
زبان مقاله : انگلیسی
محور مقاله : داده کاوی در زیست شناسی
محل انتشار : هفتمین همايش بیوانفورماتیک ايران
آدرس وب سایت کنفرانس : icb7.ir
کد IOI مقاله : XAAH-BKBGF
لینک مستقیم مقاله : https://isnac.ir/XAAH-BKBGF
سایر مقالات ارائه دهنده
- In silico evaluation and prediction of intra/inter-species relationships & properties of antigenic region 4 of HA protein of swine influenza H1N1 virus in Iran in order to present a proper candidate for vaccine
- In-silico evaluation of Iran NDV fusion protein in order to present effective vaccine candidate
سایر مقالات محل انتشار
- Registration Paper
- ACon: predicting protein contact-map using additive neural networks and subgroups balancing method
- In Silico Design, Analysis and Structure Prediction of Tow New Chimeras of VK210/VK247CSP Antigen for Development of a Malaria Pre-erythrocytic Subunit Vaccine Candidate
- Bioinformatics for Plant genome
- In silico evaluation and prediction of intra/inter-species relationships & properties of antigenic region 4 of HA protein of swine influenza H1N1 virus in Iran in order to present a proper candidate for vaccine
- In-silico evaluation of Human papioma virus L1 protein in order to present effective vaccine candidate
- Assessing the stability of a drug-like inhibitory peptide in complex with β-Catenin using umbrella sampling
- Immunogenic epitopes prediction of SP15 protein of Phlebotomus papatasi salivary gland by bioimmunoinformatic
- Molecular docking study on anticancer activity of phycocyanobilin
- Engineering of ovine pancreatic Ribonuclease for increasing of cytotoxicity activity: an in silico approach
- Feature Selection in Quantitative Structure-Activity Relationship (QSAR) Study: Combining Firefly and Neural Network methods
- Molecular Dynamics Studies of Truncated Human Cathelicidin LL:37 Peptide Interacting with a Bacterial Model Membrane
- Bioinformatic analysis of acyl carier protein (ACP) in eukaryotes and prokaryotes