Preparation of 6-mercaptopurine Imprinted hydrophilic Nanospheres as Novel Drug Delivery System

Hamed khorami¹

Abstract :
Molecularly imprinted polymers (MIPs) are synthetic tailor-made polymers with high selectivity towards a particular substance (template). An MIP using 6-mercaptopurine (6-MP) as the template molecule was synthesized and characterized. Molecularly imprinted hydrogel nanospheres as devices for the controlled/sustained release of 6-mercaptopurine in biological fluids were synthesized employing one-pot precipitation technique as the polymerization method. Methacrylic acid as a functional monomer and ethylene glycole dimethacrylate as a cross-linker were used in polymeric feed. Morphological properties were determined by scanning electron microscopy (SEM) and the binding properties of the imprinted nanospheres were studied by equilibrium binding test. Morphological and hydrophilic properties were determined by scanning electron microscopy and water content measurement, and recognition and selectivity properties of spherical molecularly imprinted polymers were compared with the spherical non-imprinted polymers, both in organic (acetonitrile) and water media. Finally,in vitro release studies were performed in plasma simulating fluids. This new MIPs nanospheres can utilize as a novel drug delivery devices due to its improved properties.
Keywords : 6-mercaptopurine (6-MP), drug delivery, nanoparticles, imprinted polymers

زبان مقاله : انگلیسی
محور مقاله : علوم
محل انتشار : دومین کنگره بین المللی علوم و مهندسی - پاریس
آدرس وب سایت کنفرانس : parisconf.com
ارسال کننده : حامد خرمی
کد IOI مقاله : XCAZ-EFBKZ
لینک مستقیم مقاله : https://isnac.ir/XCAZ-EFBKZ