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In vitro and In vivo Evaluations of Biomimetic Bi-layer Wound Dressing Composed of a Sponge Layer Containing A-PRF and a Nanofiber Layer Containing L-arginine

saeideh salehi1 Nafise Kazemi2 Marjan Mirhaj3 Mohamadreza Tavakoli4 Jaleh Varshosaz5 Sheyda Labbaf6

Abstract :
Platelet-rich fibrin (PRF) has received a great deal of attention in recent years for use in wound treatments due to release of different types of growth factors. The composition of PRF in hydrogels as a wound dressing is a less studied topic. Since monolayer wound dressings may not meet all clinical needs, it is important to design multilayer wound dressings with different characteristics in each layer. In this study, a chitosan/polyethylene glycol (CsPEG) sponge with different percentages (1, 1.5 and 2% w/v) of advanced platelet-rich fibrin (A-PRF) was prepared as the upper layer of wound dressing, and a Cs/L–arginine electrospun nanofiber layer with different percentages (0.25, 0.5 and 0.75% w/v) of L-arginine were used as the bottom layer of dressing to mimic the extracellular matrix (ECM) structure. Morphological characteristics and chemical interactions were evaluated using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), respectively. Based on the results, the wound dressings contained 1.5% of A-PRF had optimal mechanical properties and the presence of nanofiber layer in bi-layer dressings did not have a significant effect on the mechanical properties compared to sponge dressings. In addition, the release of platelet-derived growth factor-AB (PDGF-AB) and vascular endothelial growth factor (VEGF) and the release of L-arginine from the studied wound dressings were investigated. It was shown that the antibacterial activity of Bi-layer1.5 dressing against E. coli and S. aureus was significantly higher than other tested dressings due to L-arginine release.

Keywords : advanced platelet rich fibrin bi layer chitosan l arginine nanofiber sponge wound dressing

زبان مقاله : انگلیسی
محور مقاله : مهندسی مواد
محل انتشار : دومین کنفرانس بین المللی پژوهش ها و دستاوردهای نو در علوم، مهندسی و فناوری های نوین
آدرس وب سایت کنفرانس : setbconf.com/2nd
کد IOI مقاله : XEEB-GKHAB
لینک مستقیم مقاله : https://isnac.ir/XEEB-GKHAB

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  1. Fabrication and characterization of PCL/Keratin nanofiber wound dressing containing PRF: in vitro and in vivo study
  2. A Sponge wound healing accelerator containing PRF: An in vitro and in vivo Study
  3. Polycaprolactone/ Keratin/ Platelet-rich fibrin nanofiber scaffold as wound dressing: in vitro and in vivo study
  4. Fabrication, Characterization and Biological Assessment of Angiogenic Sponge Wound Dressing Containing Advanced Platelet-Rich-Fibrin
  5. In vitro and In vivo Evaluations of Biomimetic Bi-layer Wound Dressing Composed of a Sponge Layer Containing A-PRF and a Nanofiber Layer Containing L-arginine
  6. Fabrication and Evaluation of Alkali Treated Polylactic Acid Scaffold Coated by Keratin-Platelet Rich Fibrin; a Combination of 3D-Printing and Lyophilizing Methods
  7. Fabrication of an angiogenic and wound healing accelerator sponge dressing containing of blood drived growth
  8. Designing of a biomimetic bi-layer wound dressing containing of advanced-platelet rich fibrin and L-arginine: in vitro and in vivo study
  9. Preparation of Polyvinyl Pyrrolidone (PVP) / kreatine (Kr) / L-Arginine nanofibers by electrospinning method for wound healing
  10. Bi-layer Wound Dressing Made of a Sponge Layer and Nanofiber Layer
  11. Preparation of L-Arginine nanofibers by electrospinning method for wound healing
  12. Osteogenic differentiation potential of mesenchymal stem cells cultured on Poly lactic acid-Chitosan-Platelet rich fibrin scaffolds for bone tissue
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