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Fabrication and Evaluation of Alkali Treated Polylactic Acid Scaffold Coated by Keratin-Platelet Rich Fibrin; a Combination of 3D-Printing and Lyophilizing Methods

saeideh salehi1 mohamadreza tavakoli2 Sepideh Salehi3 Jaleh Varshosaz4 Sheyda Labbaf5 marjan mirhaj6 vida haghighi7

Abstract :
Three-dimensional (3D) printing is an advanced technology that has been used to fabricate tissue engineering scaffolds due to its availability, high speed and accuracy. A tissue engineering scaffold must have both macropores and micropores at the same time. Since the scaffolds prepared by 3D printing are macroporous, the simultaneous use of 3D printing and lyophilization methods was proposed to fabricate scaffolds with both macropores and micropores. In this study, polylactic acid (PLA) scaffolds were prepared by fused deposition modeling (FDM) 3D printing method and underwent alkali treatment. Then a simple keratin (Kr)- platelet rich fibrin (PRF) coating or a lyophilized Kr-PRF coating was applied and the scaffolds were named PLA/Kr-PRF and L.(PLA/Kr-PRF), respectively. Microstructure and chemical functional groups were investigated by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy, respectively. It was found that coated scaffolds had higher porosity and mechanical properties than PLA scaffold. The release of growth factors such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) from scaffolds with PRF improved cell behavior. Considering the promising results, it seems that L.(PLA / Kr-PRF) scaffold as an optimal sample can be a suitable candidate for use in bone tissue engineering applications.

Keywords : 3d printing keratin lyophilization polylactic acid platelet rich fibrin tissue engineering

زبان مقاله : انگلیسی
محور مقاله : مهندسی مواد
محل انتشار : چهارمین کنگره بین المللی مهندسی، فناوری و نوآوری
آدرس وب سایت کنفرانس : eticong.com/4th
کد IOI مقاله : XEEA-HAFGD
لینک مستقیم مقاله : https://isnac.ir/XEEA-HAFGD

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گواهی دیجیتال(دانلودی) گواهی چاپی لوح نمایه مقاله اخذ کد نمایه doi
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  1. Fabrication and characterization of PCL/Keratin nanofiber wound dressing containing PRF: in vitro and in vivo study
  2. A Sponge wound healing accelerator containing PRF: An in vitro and in vivo Study
  3. Polycaprolactone/ Keratin/ Platelet-rich fibrin nanofiber scaffold as wound dressing: in vitro and in vivo study
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  5. In vitro and In vivo Evaluations of Biomimetic Bi-layer Wound Dressing Composed of a Sponge Layer Containing A-PRF and a Nanofiber Layer Containing L-arginine
  6. Fabrication and Evaluation of Alkali Treated Polylactic Acid Scaffold Coated by Keratin-Platelet Rich Fibrin; a Combination of 3D-Printing and Lyophilizing Methods
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  12. Osteogenic differentiation potential of mesenchymal stem cells cultured on Poly lactic acid-Chitosan-Platelet rich fibrin scaffolds for bone tissue
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